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Which medication is NOT classified as an SSRI?

  1. Paxil

  2. Zoloft

  3. Wellbutrin

  4. Prozac

The correct answer is: Wellbutrin

Wellbutrin is a medication that is classified as a norepinephrine-dopamine reuptake inhibitor (NDRI), rather than a selective serotonin reuptake inhibitor (SSRI). This classification means that it primarily affects the neurotransmitters norepinephrine and dopamine in the brain, which is different from the mechanism of action seen in SSRIs. SSRIs, such as Paxil, Zoloft, and Prozac, specifically increase serotonin levels by inhibiting its reuptake into the presynaptic cell, leading to enhanced serotonergic activity. Understanding these differences in drug classification is essential for effectively managing and treating various mental health conditions.