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Which of the following antianxiety medications may initially not be effective?

  1. Alprazolam (Xanax)

  2. Lorazepam (Ativan)

  3. Buspirone (BuSpar)

  4. Diazepam (Valium)

The correct answer is: Buspirone (BuSpar)

Buspirone (BuSpar) is an antianxiety medication that often requires a certain amount of time before its full effectiveness is realized. Unlike benzodiazepines, which can provide immediate relief of anxiety symptoms, buspirone is known for its delayed onset. Patients may not notice significant improvements in their anxiety for several weeks after starting treatment, as it builds up in the system and exerts its anxiolytic effects gradually. This characteristic makes buspirone particularly different from other options listed, such as alprazolam, lorazepam, and diazepam, which are benzodiazepines and typically offer quick relief from anxiety. These medications work by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA), leading to an immediate calming effect that many patients seek for acute anxiety episodes. Thus, while effective for anxiety management, they do not have the delayed onset associated with buspirone. Understanding this pharmacological difference is important for both clinicians and patients, as it informs expectations about treatment timelines and the management of anxiety disorders.